Abstract
Objective To establish a rat model being trapped underground to study the relationship of the energy depletion with brain failure and death after fasting. Methods Thirty-six male SD rats were randomly divided into normal diet control group (n=4) and fasting group (provided with water only, n=32). Fasting group was subdivided into 3 d group, 5 d group, 7 d group and 9 d group (n=8 per group) according to the time points of 3, 5, 7 and 9 days after being trapped underground. The changes of the behavior and body weight were observed, and the brain weight and water contents were determined. Results Compared with normal diet control group, there were mild excitement and more foraging behavior in 3 d group. There was gradual declining of mental state and body weight in the other three subgroups. There were no statistically significant differences in brain weight between normal diet control group and fasting group until 9 days. Conclusion The fasting may exert obvious effect on body weight and brain weight. Key words: Underground accident; Fasting animal model; Brain dysfunction
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