Abstract
In Prediabetes blood sugar levels are found to be higher than normal levels. It is considered as pre stage of diabetes as people with prediabetes, if remain undiagnosed, have chances of developing type 2 diabetes. Studies show that if diabetes is treated in the prediabetic stage, it results in complete cure of diabetes. The objective of the present study was to investigate effect of PDBT capsules containing extracts of well-known Ayurvedic plants such as <i>Zingiber officinale, Tinospora cordifolia, Pterocarpus marsupium, Gymnema sylvester</i>, and <i>Momordica charantia</i> on prediabetic condition induced in Wistar rats. High fat fructose diet was fed to male Wistar rats to induce prediabetes. After induction on 11<sup>th</sup> week of study, the prediabetic rats were divided in different groups. Treatment groups received Pioglitazone (3 mg/kg) (standard control), test formulation, PDBT capsule (200mg/kg) (test group) along with high fat fructose diet. Normal diet control group received normal diet and high fat fructose diet control group received only high fat fructose diet. The different biochemical parameters, blood glucose levels and body weights were monitored. Animals were sacrificed at the end of study period. Histopathological studies on the major organs such as liver, kidney, pancreas was performed. High fat fructose diet induced of prediabetes in rats. Significant decrease in levels of fasting blood glucose and biochemical parameters in treatment groups was observed. The histopathological study showed no abnormalities. The present research show that PDBT capsules can be efficiently used in prediabetes treatment. Hence, PDBT capsule can be a potential agent for the treatment of prediabetes.
Highlights
Diabetes mellitus is a cluster of different disorders
10a normal control rats, 10b prediabetic control rats, 10c prediabetic rats treated with pioglitazone, 10d prediabetic rats treated with PDBT capsule ii
The results indicate that the PDBT capsules have therapeutic activity same as that of standard drug (Pioglitazone)
Summary
Diabetes mellitus is a cluster of different disorders. It is diagnosed by hyperglycemia and glucose intolerance. In diabetes there may be lack of insulin or action of insulin might be defective or both [1]. Diabetes mellitus has affected more than 170 million individuals worldwide [2]. In India the diabetes is one of the major health problem. In the treatment of the diabetes, new area for the research has been developed, that is to treat diabetes in its primary stage [3, 4]. As per Tabák A et al Prediabetes, typically defined as blood glucose concentrations higher than normal, but lower than diabetes thresholds, is a high-risk state for diabetes development [3, 5]
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