Abstract
Nowadays neurodegeneration in multiple sclerosis is closely associated with irreversible disability progression. However, the involvement sequence of different regions in atrophy is still unclear. The aim of our study was to determine the relationship between brain and spine atrophy and neurological disability in relapsing-remitting multiple sclerosis (RRMS) patients. 45 RRMS patients underwent brain and spine MRI with voxel based morphometry and neurological examination with EDSS and were compared to 20 healthy controls. As a result we determined a distinct patterns of atrophy distribution in MS patients and the sequence of involvement of different central nervous system regions. A strong correlation between disability progression rate and gray matter atrophy rate was detected.
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