Abstract
ObjectiveWe used the amplitude of low-frequency fluctuation (ALFF) method to investigate spontaneous brain activity in patients with optic neuritis (ON) in specific frequency bands.Data and MethodsA sample of 21 patients with ON (13 female and eight male) and 21 healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) scans in the resting state. We analyzed the ALFF values at different frequencies (slow-4 band: 0.027–0.073 Hz; slow-5 band: 0.01–0.027 Hz) in ON patients and HCs.ResultsIn the slow-4 frequency range, compared with HCs, ON patients had apparently lower ALFF in the insula and the whack precuneus. In the slow-5 frequency range, ON patients showed significantly increased ALFF in the left parietal inferior and the left postcentral.ConclusionOur results suggest that ON may be involved in abnormal brain function and can provide a basis for clinical research.
Highlights
Optic neuritis (ON) refers to all inflammatory lesions of the optic nerve, usually manifesting as acute or subacute vision loss with or without orbital pain, eye rotation pain, visual field defects or other clinical symptoms, and is the most common neurological disease leading to visual loss in young and middle-aged adults [1]
amplitude of low-frequency fluctuation (ALFF) values were significantly higher in ON patients than healthy controls (HCs) in the right cerebellum, the right temporal inf, the left temporal inf, and the left parietal inf, and lower than HCs in the left cingulum ant and the right cingulum ant
We have shown using fMRI that the cerebellum is involved in cognition and memory [21]
Summary
Optic neuritis (ON) refers to all inflammatory lesions of the optic nerve, usually manifesting as acute or subacute vision loss with or without orbital pain, eye rotation pain, visual field defects or other clinical symptoms, and is the most common neurological disease leading to visual loss in young and middle-aged adults [1]. A survey found that ON was the second most damaging disease among patients under 50 years of age after glaucomatous optic neuropathy [2]. ON occurs predominantly in people aged 20–50, with an average age of onset of 36 years, and more than 70% of patients are female [5]. Evidence suggests that there are ALFF Study in on Patients racial and population differences in ON, which is more common among young, middle-aged, white females [6].
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