Abstract
Objective The purpose of this study was to investigate the characteristics of different frequency bands in the spontaneous brain activity among patients with acute basal ganglia ischemic stroke (BGIS). Methods In the present study, thirty-four patients with acute BGIS and forty-four healthy controls were examined by resting-state functional magnetic resonance imaging (rs-fMRI) from May 2019 to December 2020. Two amplitude methods including amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) calculated in three frequency bands (conventional frequency band: 0.01-0.08 Hz; slow-5 frequency band: 0.01-0.027 Hz; and slow-4 frequency band: 0.027-0.073 Hz) were conducted to evaluate the spontaneous brain activity in patients with acute BGIS and healthy controls (HCs). Gaussian Random Field Theory (GRF, voxel p < 0.01 and cluster p < 0.05) correction was applied. The correlation analyses were performed between clinical scores and altered metrics values. Results Compared to HCs, patients with acute BGIS showed decreased ALFF in the right supramarginal gyrus (SMG) in the conventional and slow-4 bands, increased fALFF in the right middle frontal gyrus (MFG) in the conventional and slow-4 bands, and increased fALFF in the bilateral caudate in the slow-5 frequency band. The fALFF value of the right caudate in the slow-5 frequency band was negatively correlated with the clinical scores. Conclusion In conclusion, this study showed the alterations in ALFF and fALFF in three frequency bands between patients with acute BGIS and HCs. The results reflected that the abnormal LFO amplitude might be related with different frequency bands and promoted our understanding of pathophysiological mechanism in acute BGIS.
Highlights
Acute stroke is a prominent cause of mortality and disability worldwide and leads to a heavy burden on individual, families, and society [1,2,3]
A total of 43 patients with acute basal ganglia ischemic stroke (BGIS) and 47 healthy controls (HCs) underwent the resting-state functional magnetic resonance imaging (rs-fMRI) scan in the present study from May 2019 to December 2020
There were no significant differences in age (p = 0:736) but in gender (p = 0:007) between acute BGIS patients and HCs
Summary
Acute stroke is a prominent cause of mortality and disability worldwide and leads to a heavy burden on individual, families, and society [1,2,3]. Acute ischemic stroke which is caused by a sudden interruption of blood supply resulted from to occlusion or obstruction by a thrombus or embolus accounts for more than 80% of all strokes [4]. The basal ganglia region is rich in blood supply and is a common site of ischemic stroke [5]. Acute ischemic stroke occurring in the basal ganglia region is defined as acute basal ganglia ischemic stroke (BGIS). The acute BGIS has been considered to have association with motor impairments, sensory disturbance, emotional blunting, poststroke depression, and loss of Neural Plasticity spontaneous speech [6,7,8].
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