Abstract
Previous studies have shown that arterial stiffness, when determined invasively, is known to be a major contributor to atherosclerosis and one of the most important causes of cardiovascular disease (CVD). The aim of this study is to assess the feasibility of the arterial stiffness index (ASI) using a non-invasive computerized oscillometric device (Cardio Vision, MS-2000) and the predictive value of ASI for CVD risk level in asymptomatic individuals, and to seek cardiovascular risk factors influencing ASI. In this study, ASI was obtained using the Cardio Vision MS-2000 instrument in 316 asymptomatic, apparently healthy subjects (M/F=176/140; aged 48±11 years) who were admitted for routine physical check-ups. Family history, serum lipids and lipoproteins, glucose levels and mercury sphygmomanometer blood pressure measurements were collected. The risk for CVD in each individual was assessed by the Framingham Risk Score System. Results: Significant correlations were found between ASI and various risk factors, including age, measures of blood pressure, total cholesterol, low-density-lipoprotein cholesterol, triglyceride, and pulse rate. The multivariate regression analyses showed that age and blood pressure independently predict changes in ASI. Furthermore, ASI was significantly positively correlated with Framingham Risk Scores (r=0.324, p＜0.0001). Subjects with a 10-year risk for a future CVD events of≤10% have significantly lower ASI than those whose risk for CVD are ＞10% (50±18 vs. 58±21, p=0.001). Our findings suggest that noninvasive measures of ASI are effective in assessing cardiovascular risk. Further and larger prospective studies are still necessary, to determine whether they may provide clinicians and research scientists with another diagnostic tool in addition to standard CVD risk factors.
Published Version
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