Abstract
BackgroundMetabolic syndrome (MetS) is correlated with arterial stiffness and can be evaluated by brachial-ankle pulse wave velocity (baPWV). We investigated potential associations between MetS and baPWV in a Chinese community population.MethodsThe community-based Asymptomatic Polyvascular Abnormalities in Community study examined asymptomatic polyvascular abnormalities in a Chinese population aged ≥40 years. The relationship between MetS and its components and baPWV was analyzed by multivariate logistic and linear regression models.ResultsOut of 5181 study participants, 1271 subjects (24.53%) had MetS. Mean values of baPWV in subjects with 0, 1, 2,3, 4, and 5 components of MetS were 1430, 1526, 1647, 1676,1740, and 1860 cm/s, respectively (p < 0.001 for trend). After adjusting for confounding risk factors, MetS was significantly associated with baPWV (odds ratio [OR]: 2.74; 95% CI: 2.28, 3.30). Among the five components of MetS, elevated blood pressure was the most important factor for baPWV. All models of multivariate linear regression analysis showed a significant positive correlation between the increasing numbers of MetS components and baPWV (p < 0.0001).ConclusionsbaPWV was associated with MetS and was greater with increasing numbers of MetS components. Elevated blood pressure was the most important factor for baPWV.
Highlights
Metabolic syndrome (MetS) is correlated with arterial stiffness and can be evaluated by brachialankle pulse wave velocity
Of the 5440 subjects who were originally included into the Asymptomatic Polyvascular Abnormalities Community (APAC) study, we excluded 218 participants without measurement of brachialankle pulse wave velocity (baPWV) and 41 individuals without MetS
In our investigation based on a community population in northern China, baPWV was significantly associated with MetS and baPWV, and there was greater statistical significance with increasing numbers of MetS components
Summary
Metabolic syndrome (MetS) is correlated with arterial stiffness and can be evaluated by brachialankle pulse wave velocity (baPWV). We investigated potential associations between MetS and baPWV in a Chinese community population. Metabolic syndrome (MetS) is a pre-atherosclerotic state which involves a cluster of factors, such as abdominal obesity, arterial hypertension, dyslipidemia, and hyperglycemia, and is closely associated with a marked increase in the risk of cardio-cerebrovascular diseases and type 2. The correlation between baPWV and MetS and its components may be different based on different populations, regions and cultural diet. The purpose of the present study was to evaluate the relationship between baPWV and MetS and its individual components in a large sample size of 5181 communitybased subjects in the northern region of China, and to further elucidate the complex correlation between baPWV and MetS
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