Abstract
BackgroundThe aim of this study was to evaluate the effect of MetS on arterial stiffness in a longitudinal study.MethodsBrachial-ankle pulse wave velocity (baPWV), a measurement interpreted as arterial stiffness, was measured in 1518 community-dwelling persons at baseline and re-examined within a mean follow-up period of 3 years. Multivariate linear regression with generalized estimating equations (GEE) were used to examine the longitudinal relationship between MetS and its individual components and baPWV, while multivariate logistic regression with GEE was used to examine the longitudinal relationship between MetS and its individual components and the high risk group with arterial stiffness.ResultsSubjects with MetS showed significantly greater baPWV at the end point than those without MetS, after adjusting for age, gender, education, hypertension medication and mean arterial pressure (MAP). MetS was associated with the top quartile of baPWV (the high-risk group of arterial stiffness, adjusted odds ratio [95% confidence interval] 1.52 [1.21-1.90]), and a significant linear trend of risk for the number of components of MetS was found (p for trend < 0.05). In further considering the individual MetS component, elevated blood pressure and fasting glucose significantly predicted a high risk of arterial stiffness (adjusted OR [95% CI] 3.72 [2.81-4.93] and 1.35 [1.08-1.68], respectively).ConclusionsMetS affects the subject's progression to arterial stiffness. Arterial stiffness increased as the number of MetS components increased. Management of MetS is important for preventing the progression to advanced arterial stiffness.
Highlights
The aim of this study was to evaluate the effect of Metabolic syndrome (MetS) on arterial stiffness in a longitudinal study
In this 3-year community-based prospective study, we found that MetS and the MetS components independently predicted the future progression or incidence of arterial stiffness
Regarding the influence of individual components of MetS on arterial stiffness, we found that blood pressure and fasting glucose were independent determinants of longitudinal arterial stiffness progression in this general population
Summary
The aim of this study was to evaluate the effect of MetS on arterial stiffness in a longitudinal study. MetS has been known as a critical risk factor in the incidence of type 2 diabetes and in cardiovascular outcome [1,13,14]. A pathological condition with vascular damage, is a cardiovascular outcome of. Pulse wave velocity (PWV) is widely used to reflect arterial stiffness. A noninvasive brachial-ankle pulse wave velocity (baPWV) measurement, which is performed more than carotidfemoral PWV measurement, has been used as a marker for screening vascular damage and cardiovascular risk in the general population [18,19], in diabetes patients [20,21], in hypertension patients [22,23], in patients with end-stage renal disease [24,25], and in women with systemic lupus erythematosus [26]
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