Abstract
Bowen's 1 dermatosis is still considered by some authors as a precancerous dyskeratotic process but is regarded by the majority as a highly specialized form of superficial squamous cell epithelioma with lateral intraepithelial spread. The histologic characteristics of Bowen's disease of the skin were stated by Stout 2 as follows: The epidermal layer is thickened and sometimes made papillary by a multiplication and disorientation of the Malpighian cells. The cells vary in size and shape, there are many mitoses, and some of them are... abnormal. Monster cells with several nuclei centrally clumped together were originally described by Bowen. Darier 3 coined the term poikilokarynosis to describe these changes. Furthermore, foam cells (Kreibich 4 ) with vacuolated cytoplasm, isolated cell nests within the epithelium (Grzybowski 5 ) and cells with a clear vacuole partly or completely surrounding the nucleus ( corps ronds , Darier) are sometimes observed. Intracellular fibrils are usually lost, but intercellular
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Archives of Otolaryngology - Head and Neck Surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
