Bousigonine A and B, bis- and tri-indole alkaloids from Bousigonia mekongensis and their preventing high glucose-induced podocyte injury activity

Ya-Lan Wang,Chang-Run Guo,Yan Mu,Yun-Liang Lin,Hui-Jiao Yan,Zhi-Wei Wang,Xiao-Jing Wang

doi:10.1016/j.tetlet.2019.151042

Bousigonine A and B, bis- and tri-indole alkaloids from Bousigonia mekongensis and their preventing high glucose-induced podocyte injury activity

Ya-Lan Wang, Chang-Run Guo + Show 5 more

https://doi.org/10.1016/j.tetlet.2019.151042

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Journal: Tetrahedron Letters	Publication Date: Aug 12, 2019
Citations: 6

Affiliation: Shandong Academy of Sciences, University of Jinan, China Pharmaceutical University

#Indole Alkaloid #High Injury + Show 8 more

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Abstract

Bousigonine A (1), an unprecedented eburnamine-voaphylline type dimeric indole alkaloid, and Bousigonine B (2), the first example of eburnamine-eburnamine-aspidospermine type trimeric indole alkaloid were isolated from Bousigonia mekongensis. Their structures were elucidated mainly by spectroscopic analysis and compared to published data. Their preventing high glucose-induced podocyte injury activity were evaluated for the first time, and compound 1 exhibited significant effect with EC50 value of 2.5 μM.

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