Abstract
The present study aimed to investigate the effect of Botoxon sex hormones level which including folliclestimulatinghormone (FSH), luteinizing hormone(LH)and progesterone in female rats and measurement ofserum lipid profile. Two doses 0.1/animal and 0.2 ml/animal from Botox were used and the animals wereinjected intramuscular of botulinum toxin for 1 day as two doses only. The results showed a significantdecrease (P<0.05) in the level of FSH and LH, with a significant increase the level of progesterone of thefemale treated with 0.1 ml and 0.2 ml of Botox compared with the control group. The results showed asignificant increase in the level of cholesterol, TG, HDL, LDL and VLDL of the female treated with Botoxatdose 0.2 ml when compared with the control group. While,the female treated with Botoxat dose 0.1 mlthere was no a significant in level of cholesterol compared with control group. Also, there was a significantdecrease of HDL of female rats treated with Botox compared with control group. Injections of femalerats with botulinum toxin are generally well tolerated and side effects are few. A precise knowledge andunderstanding of the functional anatomy of the mimetic muscles is absolutely necessary to correctly usebotulinum toxins in clinical practice.
Published Version
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