Boswellic Acids Pretreatment Enhances the Bioavailability and Hypoglycemic Action of Metformin in Rats: Involvement of CYP3A Inhibition

Ciddi Veeresham,

doi:10.31531/2581-3080.1000132

Abstract

Boswellic Acids Pretreatment Enhances the Bioavailability and Hypoglycemic Action of Metformin in Rats: Involvement of CYP3A Inhibition

Highlights

Herbal drugs have received great attention as alternative medicines in recent years and are referred to as a dietary supplement or health food
From the pharmacokinetic study of normal and diabetic rats it was found that the Cmax of metformin significantly increased in boswellic acids (BA) with metformin (1.51, 2.46 times), AUC0-n (2.07, 3.68 times), AUC total (2.36, 5.22 times), t1/2 (1.65, 2.32 times), MRT (1.46, 2.05 times), whereas the clearance and volume of distribution of metformin was decreased 0.43, 0.73 times in normal rats and 0.19, 0.45 times in diabetic rats, when compared with control group
The Tmax of metformin in both normal and diabetic groups was not altered by co administration with BA

Summary

Introduction

Herbal drugs have received great attention as alternative medicines in recent years and are referred to as a dietary supplement or health food. For glucose tolerance test 30 minutes after the treatment all the group of rats were given D-glucose (2.5 g/kg, p.o) and blood samples were collected at time intervals of 30, 60, 90 and 120 minutes for estimation of blood glucose levels, same as mentioned in earlier reported method [17].

Results

Conclusion