Abstract
Multiply halogenated aromatic compounds were selectively borylated by a boron alkoxide in the presence of sodium dispersion when the reaction was carried out at a low temperature, while multi-functionalization took place at an elevated temperature. The reaction of 1,4-dichlorobenzene with sodium dispersion (200-1200 mol%) in the presence of isopropyloxyboron pinacolate (120-240 mol%) afforded (4-chlorophenyl)boron pinacolate in up to 84% yield. Formation of diborylated product hardly accompanied under the reaction conditions at -78 °C for 1 h.
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