Abstract
In order to take the advantages of micro/nano-topography and benefits of boron (B), B-containing micro/nano-structured TiO2/bioceramics coatings were developed on titanium (Ti) substrates for enhanced osteogenesis. The micro-arc oxidation was employed to fabricate a micro-topographical TiO2 layer (referred as Micro-Ti). Then, the second layer of nano-rods was prepared on Micro-Ti surface via hydrothermal treatment (referred as Hier-Ti). These nano-rods transformed to nano-particles after a post heat treatment (referred as Hier-HT-Ti). The adhesion, proliferation and differentiation of SaOS-2 cells were inhibited on Hier-Ti, but promoted on Hier-HT-Ti. The results indicate that the development of B-containing micro/nano-topographical coatings on Ti substrates could lead to enhanced osteogenesis.
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