BONE SEVERE FORM OF HYPERPARATHYROIDISM IN A PATIENT WITH ADENOMA OF PARATHYROID GLAND

K M Petrosyan,V N Galkin,G A Davydov,A A Kuril'Chik,N V Zhelonkina,E I Kupriyanova,A V Dement'Ev,A D Kaprin,D N Derbugov,N V Severskaya,S A Ivanov

doi:10.17709/2409-2231-2018-5-1-11

Abstract

Hyperparathyroidism is one of the most common endocrinopathies. This disease leads to a violation of phosphorus-calcium metabolism and the washing out of calcium from bone tissue. Breach of the skeleton’s structure in hyperparathyroidism is often mistaken for metastatic bone damage, which leads to incorrect treatment tactics. In this work we present the clinical observation of a patient with an adenoma of the parathyroid gland and a severe bone form of hyperparathyroidism. Multiple lesions of bones with destruction of the cortical layer and the presence of the softtissue component were initially regarded as metastases in the bone. However, the morphological pattern of bone foci, as well as an elevated level of calcium and parathyroid hormone, made it possible to diagnose the bony form of hyperparathyroidism. The search for the cause of hyperparathyroidism revealed a tumor in the projection of the right lower parathyroid gland. Surgical removal of parathyroid adenoma led to the normalization of the level of calcium and parathyroid hormone. The article presents data of laboratory-instrumental methods of research and the results of surgical treatment of a patient.

Highlights

Первичный гиперпаратиреоз — эндокринное заболевание, вызываемое опухолевыми или гиперпластическими изменениями одной или нескольких паращитовидных желез, приводящее к нерегулируемой гиперсекреции паратгормона, гиперкальциемии и ряду патологических изменений, прежде всего в костях и почках [1]
In this work we present the clinical observaƟon of a paƟent with an adenoma of the parathyroid gland and a severe bone form of hyperparathyroidism
Brown tumor with fluid-fluid levels in a paƟent with primary hyperparathyroidism: radiological finding

Summary

Introduction

Первичный гиперпаратиреоз — эндокринное заболевание, вызываемое опухолевыми или гиперпластическими изменениями одной или нескольких паращитовидных желез, приводящее к нерегулируемой гиперсекреции паратгормона, гиперкальциемии и ряду патологических изменений, прежде всего в костях и почках [1]. For citation Petrosyan K.M., Severskaya N.V., Derbugov D.N., Kuril’chik A.A., Zhelonkina N.V., Dement’ev A.V., Kupriyanova E.I., Davydov G.A., Kaprin A.D., Galkin V.N., Ivanov S.A. Bone severe form of hyperparathyroidism in a patient with adenoma of parathyroid gland. 96-105 K.M.Petrosyan, N.V.Severskaya, D.N.Derbugov, A.A.Kuril’chik et al /Bone severe form of hyperparathyroidism in a patient with adenoma of parathyroid gland Множественные очаги патологической гиперфиксации радиофармпрепарата в проекции костей таза, левой бедренной кости и грудного отдела позвоночника на уровне Th11.

Results

Conclusion