Abstract

The effect of a low phosphorus diet on bone resorption is studied in thyroparathyroidectomized rats. Bone resorption is estimated from the marrow cavity area of a cross-section of the tibia. The rate of calcium mobilisation from bone is estimated by serum specific activity of45Ca/40Ca after labelling of the diet. Bone resorption is increased by feeding a low phosphorus diet, suggesting a direct effect of hypophosphatemia stimulating bone resorption, independent of any action of parathyroid hormone.

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