Abstract
Bone Research Society Abstracts
Highlights
Decellularized tissue matrices offer a valuable substitute for biomimetic scaffolds in tissue engineering given their innate preservation of native extracellular matrix (ECM) and integral tissue architecture
By mapping genomewide expression quantitative trait loci, we identified a co-expression network of 143 trans-regulated genes associated with macrophage multinucleation (MMnet) that was enriched for known osteoclast genes
This study clearly demonstrates the need for more research and evidence generation in these patients
Summary
Decellularized tissue matrices offer a valuable substitute for biomimetic scaffolds in tissue engineering given their innate preservation of native extracellular matrix (ECM) and integral tissue architecture. HBMSCs cultured on hECM-Laponite films were viable after 7 days, showing that these gel composites with increasing concentrations of ASAP provide an environment for cell infiltration and proliferation. Conclusion: The current studies have demonstrated the addition of Laponite enhances mechanical properties and stability of hECM, confirming its promise as a bioactive scaffold to augment bone regeneration. A hyaluronan (HA) hydrogel with covalently linked bisphosphonate (BP) ligands (HABP) shows a sustained release of bone morphogenetic protein (BMP)-2 in vitro As another hydrogel candidate as a molecule carrier, laponite (LAP) gel based on clay-nanoparticle was shown to enhance BMP-2 localization in the gel, resulting in the improved bone formation. Objectives: In this study, we focused on the effect of LAP in HABP (HABP–LAP) hydrogel on the in vitro and in vivo release profiles of BMP-2 for bone regeneration. Conclusion: Overall, the patterns of bone remodeling after osseointegration showed similarities to those seen on hip stems
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