Abstract
Bone is a dynamic tissue that undergoes continuous remodeling throughout life. Regulated by intrinsic factors and external stimuli, bone remodeling is an essential physiological activity for the maintenance of normal bone mass and strength and for systematic mineral homeostasis in terrestrial animals. Coupled bone remodeling is key to maintaining the structural integrity and mechanical homeostasis of bone in adulthood, and it is modulated by multiple factors and signaling pathways. Herein, we review the bone remodeling process and its critical role in maintaining bone homeostasis. We discuss the interactions between bone and other tissues and how these interactions regulate bone remodeling.
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