Abstract
Serum concentrations of vitamin D metabolites (chromatography) and bone mineral status (125I absorptiometry) were examined in a group of Aleutian Islanders age 40-75 from St Paul Island, Alaska. Based on 25-(OH)D (16.6 ng/ml) vitamin D status appeared adequate. However, high concentrations of 1,25-(OH)2D (44.3 pg/ml) and very low concentrations of 24,25-(OH)2D3 (0.6 ng/ml) were found. Among females, low bone mineral levels were associated with high concentrations of 1,25-(OH)2D. A low calcium intake in these Aleutians may be responsible for high concentrations of 1,25-(OH)2D and resorption of calcium from bone.
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