Bone Marrow Mesenchymal Stem Cell (BMSC) Ameliorates the Damage of Inflammatory Bowel Disease (IBD) Rats Through Regulation of Stromal Cell-Derived Factor 1/C-X-C Chemokine Receptor Type 4 (SDF-1/CXCR4) Axis

Abstract

This study assesses the effect and mechanism of BMSC in IBD rat. Fifty SDF-grade rats were assigned into divided into NC group, model group, BMSC group, blocking agent group and positive NC group randomly with 10 rates in each group. The histopathological changes of colon tissue, expression of Musashi-1, DAPI, SDF-1 and CXCR4 was measured. There was notable inflammatory cell infiltration in model group and agonist group. The structure of gland was destructed notably with notable-visible phenomenon of hyperemia and edema in colon tissue. They could be improved significantly in positive control group and BMSC group. The necrotic colonic mucosal tissue began to be recovered slowly. The phenomenon of hyperemia and edema was alleviated notably without abnormality in colon tissue in control group. The positive level of Musashi-1 in control group, model group and agonist group was the highest. In conclusion, BMSC could be migrated into colonic damage position and differentiated into intestine stem cells to exert recovery effect on IBD rats. The molecular mechanism might be related with SDF-1/CXCR4 axis.