Abstract
Bone-marrow cell culture and kinetics were studied in 24 patients with chronic or subacute myelomonocytic leukemia. In comparison to chronic myeloid leukemia and refractory anemia with excess of blast cells, marrow cultures showed that chronic myelomonocytic leukemia follows the development of an abnormal granulomonocytic-progenitor clone different from those of the above two diseases. This clone maintains a high proliferative rate for a relatively long time. The combined kinetics and culture data indicate that the major prognostic factors, alone or associated, are: a decrease in bone marrow erythropoiesis evaluated by 59Fe kinetics or 111In scanning, a decreased labelling index of myeloblasts and promyelocytes after labelling with 3H-thymidine in vitro, and an abnormal growth of myeloid progenitors in bone marrow cultures, which may be estimated by an increased cluster:colony ratio. The importance of these kinetics data for therapeutic indications are discussed.
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