Abstract
Background Diagnosis of bone and soft tissue tumors is generally difficult, as they have heterogeneous biologic behavior patterns.1Early detection and accurate grading or classification of these tumors can improve the overall outcome and prognosis. The classification and staging of soft-tissue and bone neoplasms is evolving and depends on multiple factors and staging methods including clinical, radiographic, and histological features2 (Table 15.1). The American Joint Committee on Cancer and the Musculoskeletal Tumor Society systems are the most commonly used staging methods for bone and soft tissue tumors.2-7 High-grade tumors with evidence of metastases are reported to be associated with a poor prognosis for all bone and soft tissue neoplasms regardless of the staging system that is used.2 The size of the tumor, the anatomical compartment, and the depth of tumor invasion are also considered to be important variables.2
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