Body weight and bone/calcium metabolism. Relationship between insulin/glucose metabolism and bone/calcium metabolism.

Abstract

Recent advances demonstrated that osteoporosis is one of the major complications in diabetes. In Diabetic conditions, both bone material properties and bone microarchitecture are impaired, resulting in the decline in bone strength. Furthermore, bone-derived osteocalcin stimulates insulin secretion, thereby regulates the whole body glucose metabolism. Thus, it was revealed that bone metabolism and glucose metabolism are intimately involved.