Body mass index in girls with idiopathic central precocious puberty during and after treatment with GnRH analogues.

A. J. Arcari,M. G. Gryngarten,M. E. Escobar,A. V. Freire,M. G. Ballerini,M. G. Ropelato,I. Bergadá

doi:10.1186/s13633-016-0033-7

Abstract

BackgroundIn girls with Idiopathic Central Precocious Puberty (ICPP) concern has been raised by the potential impact of GnRH-analogues (GnRHa) treatment on body weight. We evaluated the effect of GnRHa on Body Mass Index (BMI) in girls with ICPP according to weight status at diagnosis.MethodsOne hundred seventeen ICPP girls were divided according to pretreatment weight status in: normal weight (NW), overweight (OW) and obese (OB). BMI at one and two years of treatment was assessed. BMI-SDS of 60 patients who reached adult height (AH) was compared to that of 33 ICPP untreated girls.ResultsNW girls significantly increased their baseline BMI-SDS at 1 and 2 years of treatment. OW girls only had a significant increment at one year of treatment while OB girls showed no BMI-SDS change. Patients evaluated at AH (at least four years after GnRHa withdrawal) showed a significant decrease on BMI compared to baseline and a significantly lower BMI than the untreated group.ConclusionIn ICPP girls the BMI increase under GnRHa was inversely related to the pretreatment weight status. In the long term follow-up, no detrimental effect of GnRHa on body weight was observed. BMI-SDS was lower in treated than in untreated girls.

Highlights

In girls with Idiopathic Central Precocious Puberty (ICPP) concern has been raised by the potential impact of GnRH-analogues (GnRHa) treatment on body weight
The aim of the present study was to evaluate the impact of GnRHa therapy on Body Mass Index (BMI) in girls with Idiopathic CPP (ICPP) according to weight status at diagnosis up to adult height (AH)
No significant difference in chronological age was observed among groups, p: ns (Table 1)

Summary

Introduction

In girls with Idiopathic Central Precocious Puberty (ICPP) concern has been raised by the potential impact of GnRH-analogues (GnRHa) treatment on body weight. Central Precocious Puberty (CPP) results from the premature activation of the hypothalamo-pituitary-ovarian axis In girls, it is defined as the onset of secondary sexual development before the age of 8 with further progression, accompanied by increased growth velocity and bone age acceleration usually leading to adult height impairment. While some studies have reported association between GnRHa treatment and Body Mass Index (BMI) increase [1,2,3,4,5,6,7], The aim of the present study was to evaluate the impact of GnRHa therapy on BMI in girls with Idiopathic CPP (ICPP) according to weight status at diagnosis up to adult height (AH). The subgroup of patients who achieved AH was compared to a control group of untreated ICPP girls

Objectives

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Discussion

Conclusion