Abstract
The microwave-assisted one-pot three-component reaction of 2-phenyl-7,8-dihydroquinazolin-5(6H)-one, 2-arylidenemalononitrile and ammonium acetate under solvent-free conditions occurred through a five-step multiple bond-forming transformation to afford 2-amino-8-phenyl-4-aryl-5,6-dihydropyrido[2,3-f]quinazoline-3-carbonitriles in excellent yields. All the quinazoline-3-carbonitriles exhibited bright blue fluorescence under a UV lamp and were found to be efficient chemosensors of picric acid with detection limits in the nano-molar range.
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