Abstract
Blood-Brain Barrier Breakdown and Blood-Brain Communication in Neurological and Psychiatric Diseases
Highlights
Transport across the blood-brain barrier (BBB) is tightly regulated by at least four different cells that comprise the brain microvasculature: the endothelial cell and highly specific tight junctions between them, the pericytes which share with the endothelial cells a common capillary basement membrane, the astrocytic foot processes which cover the capillaries, and nerve endings which innervate the vessels
Dysfunction of the BBB occurs during numerous common neurological diseases, including stroke, epilepsy, trauma, tumors, and infectious and degenerative diseases
While it has been long recognized that BBB dysfunction is associated with brain diseases, only recently it has been suggested to play a role in the pathogenesis of neuronal networks dysfunction and degeneration
Summary
Blood-Brain Barrier Breakdown and Blood-Brain Communication in Neurological and Psychiatric Diseases In this special issue clinical and experimental evidence for the involvement of BBB dysfunction in the pathogenesis of seizures and epilepsy Marchi et al “the etiological role of blood-brain barrier dysfunction in seizure disorders” and L.
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