Abstract
The goal of this study was to enhance the blood responses to titanium (Ti) surfaces used for dental implant application through the formation of a TiO2 nano-mesh surface layer produced by a fast electrochemical anodization treatment. Electrochemical anodization treatments with different anodization currents and temperatures in an alkaline solution were used to create a nano-mesh oxide layer on polished Ti surface. Surface characterizations of the mesh structure were carried out using thin-film X-ray diffractometer, field-emission scanning electron microscope, and atomic force microscope. The blood responses, including the blood-clotting ability and platelet adhesion morphology, to the test Ti surfaces were evaluated. The blood-clotting ability, in terms of optical density of blood, was statistically analyzed using a nonparametric method, Kruskal-Wallis test, for the factor of anodization treatment. A multilayer TiO2 nano-mesh structure was rapidly formed on the polished Ti surface using a simple electrochemical anodization treatment in an alkaline solution. The TiO2 nano-mesh had an average mesh size between 34 and 93 nm, depending on the anodization current and temperature. The features on the TiO2 nano-mesh structure on the anodized Ti surface were of a similar size scale as blood proteins, giving the material better blood clot ability (P<0.05) and improved platelet activation and aggregation as compared with an untreated polished Ti surface. The formation of TiO2 nano-mesh on the Ti surfaces was shown to enhance blood responses, which we expect to promote cell growth in the application of dental implants.
Published Version
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