Blood Protein Variation among a Population Living in Okinawa Prefecture

Abstract

Inherited variations of serum haptoglobin (Hp), transf errin (Tf), red cell acid phosphatase (AcP), adenosine deaminase (ADA), esterase D (EsD) and phosphoglucomutase (PGM) have been studied on the samples taken from the inhabitant) in Naha, Okinawa pref., who were both the apparently healthy donors and the patients suffering from various diseases.The gene frequencies for respective traits are as follows: Hp; Hp1=0.2268 and Hp2=0.7732 (n=485), Tf; Tfc=0.9876 and Tfd=0.0124 (n=485, x2(1)=12.6551, P<0.001), AcP; Pa=0.2817 and Pb=0.7183(n=600, x2(1)=10.9478, P<0.001), ADA; ADA1=0.9833 and ADA2=0.0167 (n=600), EsD; EsD1=0.6531 and EsD2=0.3469 (n=591), and PGM; PGM11=0.7158, PGM12=0.2683, PGM17=0.0142 and PGM15j=0.0017 (n=600).Except for in the Tf and AcP polymorphism, the observed numbers and those expected from the calculation assuming Hardy-Weinberg equilibrium are very similar and the observed numbers do not deviate significantly from expectation. In the case of Tf, the discrepancy is explained by an accidental presence of rare Tf DD homozygote. The condition which causes the discrepancy in the AcP phenotypic distribution is discussed.