BLOOD PRESSURE LOWERING EFFICACY OF TELMISARTAN, AZILSARTAN, OLMESARTAN TAKING ON THE MORNING OR AT BEDTIME IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION

Abstract

Objective: Aim study was compared the antihypertensive effects of morning (a.m.) and evening (p.m.) dosing of olmesartan, azilsartan, telmisartan on 24-h BP. Design and method: 126 patients (57 men, 69 women) was included in 12-week study with evaluated the efficacy and safety of olmesartan 20–40 mg (n = 40), azilsartan 40–80 mg (n = 41), telmisartan 40–80 mg (n = 45), dosed a.m. or p.m., in patients with grade 1–2 hypertension. Mean ages 51,80 ± 1,31, BMI - 28,81 ± 0,39 kg/m2. Mean 24SBP – (135,60 ± 0,96) mmHg., 24DBP – (82,41 ± 0,84) mmHg., 24HR – (71,88 ± 0,89) b.p.m. Results: Mean 24-h SBP/DBP change from baseline to Weeks 12 in olmesartan group was benefit (−11,09 ± 2,30/8,38 ± 2,58 mmHg) in p.m. compared (−4,06 ± 2,25/3,38 ± 2,31mmHg) in a.m., p < 0,01 between evening and morning administration. Mean 24-h SBP/DBP change in azilsartan group was comparable in p.m. (−13,06 ± 2,65/9,76 ± 1,73 mmHg) and a.m. (−12,71 ± 1,62/7,00 ± 1,50 mmHg) in a.m., p > 0,05 between evening and morning. Mean 24-h SBP/DBP change from baseline to Weeks 12 in telmisartan group was benefit (−16,48 ± 2,86/12,56 ± 2,80 mmHg) in a.m. compared (−4,93 ± 1,53/5,40 ± 1,89 mmHg) in p.m., p < 0,01 between morning and evening administration. All treatments were well tolerated. At 24-h BP, with the administration of olmesartan, azilsartan and telmisartan, the target blood pressure levels were 71.80%, 71.05% and 75.61% respectively. Thus, all three drugs have equally effectively. Conclusions: Taking telmisartan more significantly reduced the 24-h BP in the morning compared with the evening adminisrtation, olmesartan lowered 24-h BP better in the evening administration, and the use of azilsartan equally decreased 24-h BP, regardless of the time of taking the drug.