Abstract
Aim: This study intended to investigate the ability of blood MALT1 to estimate acute exacerbation risk in elderly chronic obstructive pulmonary disease (COPD) patients. Methods: Blood MALT1 was detected in 176 elderly COPD patients (aged more than 60years). Results: MALT1 was elevated in patients with COPD acute exacerbation versus patients with stable COPD (p<0.001). In patients with COPD acute exacerbation, MALT1 was negatively related to forced expiratory volume in 1s (FEV1)/forced vital capacity (FVC) (p=0.024) and FEV1% predicted (p=0.002), but positively linked with global initiative for chronic obstructive lung disease stage (p=0.005). Conclusion: Blood MALT1 reflects increased acute exacerbation risk and inflammation in elderly COPD patients.
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