Abstract
Lipids from platelet-rich plasma in cases of ischaemic heart disease have been compared with those from normal subjects and the thromboplastic activities of all fractions tested by the Stypven test. The fatty acid composition of the fractions has been determined. Total cholesterol and sphingomyelin were increased in ischaemic heart disease. Increased clotting activity in ischaemic heart disease was found both with platelet-rich and with platelet-poor plasma. Only the cephalin fractions were active in clotting tests. Although the levels of total cephalin were similar in the two groups, the patients' cephalin had uniformly higher clotting activity and a markedly higher oleic acid content. The triglycerides also had a significantly higher oleic acid content in ischaemic heart disease.
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