Blood lactate, pH, base excess and pCO2 as prognostic indicators in caesarean-born kids from goats with pregnancy toxaemia

I M Andrade,P B A Simões,N Carolino,M S Lima,L P Lamas

doi:10.1186/s13620-019-0149-1

I M Andrade, P B A Simões + Show 3 more

Open Access

https://doi.org/10.1186/s13620-019-0149-1

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Abstract

The objective of this study was to identify the prognostic value for survival of blood parameters in the immediate post-caesarean surgery period in kids born from pregnancy toxaemia (PT) goats. This study involved 10 PT goats, in which a caesarean surgery was performed. Twenty-five kids were born after caesarean surgery of which 16 survived. A blood sample was collected from the jugular vein of the 10 goats and from the kids immediately after caesarean surgery (within 15 min). There were differences between the kids that survived and the kids that did not survive concerning the blood levels of pH (7.22 vs 7.00), base excess (− 9 vs − 18 mmol/L), pCO2 (46 vs 62 mmHg) and L-lactate (5.6 vs 16 mmol/L). Maternal ketoacidosis due to PT has a negative impact on the survival rate of the offspring. This appears to be associated to a metabolic acidosis of the offspring. However, the only blood parameter in which there was a strong association between the maternal and newborn kids was blood urea nitrogen (r = 0.97).

Highlights

Pregnancy toxaemia (PT) is a disease that occurs in small ruminants during the last month of gestation when there is a large demand of glucose by the developing foetus [1, 2]
Several studies have shown blood parameters changes in PT goats. It has been reported a marked increase in L-lactate concentration in the blood collected from the umbilical vein [4], and marked alterations in Na+, K+, Cl−, glucose, pH, HCO3−, base excess (BE), Partial pressure of carbon dioxide (pCO2) and blood urea nitrogen (BUN), in blood collected from the jugular vein [5]
This study involved 10 PT goats and 25 kids born after a caesarean surgery

Summary

Introduction

Pregnancy toxaemia (PT) is a disease that occurs in small ruminants during the last month of gestation when there is a large demand of glucose by the developing foetus (es) [1, 2]. The disease is characterized by a marked metabolic acidosis (ketoacidosis) [1, 2]. Studies in sheep showed that maternal ketoacidosis may result in biochemical and acid-base foetal abnormalities associated with changes in fetoplacental unit perfusion [3]. Several studies have shown blood parameters changes in PT goats. It has been reported a marked increase in L-lactate concentration in the blood collected from the umbilical vein [4], and marked alterations in Na+, K+, Cl−, glucose, pH, HCO3−, BE, pCO2 and BUN, in blood collected from the jugular vein [5]. Literature data on blood parameters of newborn kids from PT goats and their association with a lower survival rate is scarce or even inexistent.

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