Abstract
Lead is one of the heavy metal humans are often expose to either through food, cosmetics or environment. This study is aimed at investigating the positive effect of Solanum melongena (garden egg), Solanum lycopersicum (tomatoes) and Daucus carrots subsp.sativus (carrot) on blood glucose concentration, body weight, and feeding habits of albino rats on lead toxicity. In this study 35 albino rats weighing 80-120g were grouped into five. Group 1 served as normal control, group 2 negative control. The remaining three groups served as treatment groups 1, 2 and 3. All groups except group 1 (normal control) were administered 50mg/kg of lead acetate. Treatment groups were administered 200mg/kg of Solanum melongena (garden egg), Solanum lycopersicum (tomatoes) and Daucus carrots subsp.sativus (carrot). Group 3 was administered Solanum malongen and Daucus carrots subsp.sativus while group 4 was given Daucus carrots subsp.sativus and solanum lycopersicon. Group 5 was administered Solanum malongen, Daucus carrots subsp.sativus and Solanum lycopersicon. Changes in blood glucose concentration, body weight, feed and water consumption recorded at intervals. The result showed a significant decrease (P<0.05 and P<0.01) in blood glucose concentration in treatment groups compared to negative control. There was also significant increase (P>0.05, P>0.01 and P>0.001) in body weight and feed consumed in treatment groups compared to negative control. Combined therapy of any two of Solanum malongen, Daucus carrots subsp.sativus and Solanum lycopersicon juice can help in the management of hyperglycemia and reverse internal abnormality or injury resulting in weight loss in lead induced toxicity.
Highlights
Lead poisoning accounts for almost 0.6% of the world disease, diabetes being one of them (WHO, 2009)
Group 4 and 5 had body weight 126g and 122g respectively compared to group 2 with 137.2 ± 09
The result of lead acetate induced toxicity obtained from this study showed a decrease body weight in both the treatment and negative control groups
Summary
Lead poisoning accounts for almost 0.6% of the world disease, diabetes being one of them (WHO, 2009). A common route of lead exposure in humans occurs early in childhood by ingestion of lead-contaminated household dust Over the millennia lead as been used in production of diverse products like; pipes, glazes, vinyl products, storage batteries, pigments and paints, cable covers, radiation shielding, weights shot and ammunition (Bener, et al 2001). In a study with factory workers in the United Arab Emirates, some significant positive correlations between blood lead levels and fasting blood glucose were observed. This finding suggests a possible link between lead toxicity and diabetes (Bener, et al 2014)
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