Abstract
ABSTRACT The effect of methylthiouracil (MTU, 0.2% in the food for 7 days) on the thyroid blood flow (86Rb method) and radioiodine uptake in rats was studied. MTU administration causes an increase of thyroid weight (about double) and an increase in blood flow (about four times, as expressed in percentages of dose 86Rb/g), while the radioiodine uptake is inhibited. After the discontinuation of MTU administration 1. the thyroid weight slowly decreases; 2. the thyroid blood flow falls from the 1st day, while on the 7th day it reaches the normal level, when expressed in percentages of dose 86Rb/g; the values in percentages of dose 86Rb in the thyroid gland remain higher than the normal; 3. radioiodine uptake rises rapidly, and on the 2nd day it reaches the normal level when expressed in percentages of dose 131I/mg; the values in percentages of dose 131I in the thyroid gland are higher than normal. Thus, during the period of action of MTU and after its discontinuation, the 86Rb uptake in the thyroid gland as an indicator of blood flow reflects the presumed concentration of endogenous thyrotrophin.
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