Abstract
ABSTRACT The effect of carbimazole (0.02 % in the food for 7 days) and potassium perchlorate (1 % in the food for 7 days) on the blood flow (86Rb method) and radioiodine uptake in the thyroid gland of rats was studied. The administration of both drugs results in an increase in the thyroid blood flow (higher after carbimazole); after discontinuation, the thyroid blood flow in both cases returned to normal levels within 7 days. The radioiodine uptake after the discontinuation of carbimazole exhibits a marked rebound on the 1st and 2nd day, whereas after discontinuation of perchlorate it exceeds the normal level on the 4th–7th day. Thus, our present and previous studies reveal qualitatively the same changes in the thyroid blood flow after the administration and discontinuation of carbimazole, perchlorate and methylthiouracil, this in all probability being due to variations in the TSH level. The rebound phenomenon in the radioiodine uptake, demonstrable after both carbimazole and perchlorate, however, shows a different temporal characteristic.
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