Abstract
Preclinical research of biomedical optoelectronic devices is often performed with the use of blood phantoms — a simplified physical model of blood. The aim of this study is the comparison and distinction between blood phantoms as well as whole human blood measurements. We show how the use of such phantoms may influence the incorrect interpretation of measured signal. On the other hand, we highlight how the use of blood phantoms enables to investigate the phenomena that otherwise are almost impossible to be noticed.
Highlights
Novel optical measurement[1,2,3,4] and imaging[5,6,7,8,9] methods for biomedicine require preclinical optimization and calibration. Such calibration is performed on standardized phantoms — simplied physical models of tissues.[10,11,12]
A physical blood phantom is obtained by suspension of red blood cells (RBCs) into the isotonic saline solution
Blood phantoms are commonly used in biomedical research as a simplied physical model of human blood
Summary
Novel optical measurement[1,2,3,4] and imaging[5,6,7,8,9] methods for biomedicine require preclinical optimization and calibration. Such calibration is performed on standardized phantoms — simplied physical models of tissues.[10,11,12] Especially, phantoms simulating optical properties of skin[13,14,15] are used for testing noninvasive optical devices.
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