Abstract
A 62-year-old female patient received hemocoagulase for injection 1 KU, added into 10 ml of 0.9% sodium chloride injection in advance, by intravenous injection thrice daily after cholecystectomy. No abnormalities of preoperative blood coagulation test were found. On day 3 after the medication, the patient had extensive capillary hemorrhage from her surgical incision. The blood coagulation test showed prothrombin time (PT) 18 s, international normalized ratio (INR) 1.5, activated partial thromboplastin time (APTT) 36 s, thrombin time (TT) 88 s, fibrinogen (FIB) 0.09 g/L, and D-dimer 3.6 mg/L. Considering that the blood coagulation disorders might be caused by hemocoagulase, it was stopped and aminomethylbenzoic acid injection 0.3 g, added into 100 ml of 0.9% sodium chloride injection in advance, was given by intravenous infusion once daily. In the meantime, vitamin K1 10 mg it was given by intramuscular injection twice daily. The next day, no significant capillary hemorrhage was found in the surgical incision. Five days later, the blood coagulation test showed PT 14 s, INR 1.0, APTT 29 s, TT 20 s, FIB 2.25 g/L, and D-dimer 0.5 mg/L. Key words: Thrombin; Blood coagulation disorders; Snake venoms; Hemocoagulase
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