Blood cells separation microfluidic chip based on dielectrophoretic force

Abstract

The paper proposed a dielectrophoresis microfluidic chip for particle separation, which uses dielectric properties to perform size-based fractionation of blood cells. Using the principle of control variables, the value range of each parameter satisfying the separation condition was calculated by MATLAB and COMSOL software simulation and the specific parameters were selected to simulate the motion trajectory of cells in the microfluidic channel. At this time, all three kinds of particles were negative dielectrophoretic responses. The spheroid white blood cells were subjected to a stronger dielectrophoretic force than red blood cells and platelets, biased toward the right exit. Platelets and red blood cells flowed out from the left and middle outlets, respectively, under the combined action of fluid force and dielectrophoretic force to achieve the purpose of separation.