Abstract
Delivery of peptide and protein drugs to the central nervous system from the blood is subject to the permeability limitations imposed by the blood-brain barrier. Recent development of an in vitro model permits the opportunity to explore fundamental blood-brain barrier characteristics at the cellular and biochemical level. In part, information generated from such studies will be necessary to develop strategies for delivering blood-borne therapeutic peptide and proteins across the blood-brain barrier to central nervous system sites of action. Reviewed here are applications of the in vitro model in studies of the biochemistry of both peptide regulation of transcellular vesicular pathways and transmembrane transport of peptides.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
