Abstract
Letters1 July 1994Blood Alcohol Levels after Prolonged Use of Histamine-2-Receptor AntagonistsAlessandro Casini, MD, Francesco Mari, PhD, and Calogero Surrenti, MDAlessandro Casini, MDUniversita di Firenze; Firenze; ItalySearch for more papers by this author, Francesco Mari, PhDUniversita di Firenze; Firenze; ItalySearch for more papers by this author, and Calogero Surrenti, MDUniversita di Firenze; Firenze; ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-1-199407010-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Our in vivo study results do not negate the in vitro evidence but rather show that the potential inhibition of gastric alcohol dehydrogenase by H2-receptor antagonists has no effect on the systemic bioavailability of ethanol when used clinically. We found no difference in measured gastric alcohol dehydrogenase activity in patients before and after treatment. An important characteristic of our study was the demonstration of a significant first-pass metabolism of ethanol (53%) in all patients before entering the study. We can assume that differences in the area-under-the-curve reflect differences in first-pass metabolism of ethanol, and it is difficult to ...
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