Blister as A Cutaneous Manifestation of Sjogren’s Syndrome Determines IL-6 Antibody to Be A Potential Treatment: A Case Report

Abstract

A 64 years old female was admitted to hospital due to having repeated blister on skin. Her Dsg1, Dsg3, Bp180, Bp230, VII collagen antibodies were all negative while her ENA-SSA and anti-CCP were positive. Labial glands biopsy revealed that lymphocytes immersed around the glands and a diagnose of Sjögren’s syndrome (SS) was made. Skin biopsy indicated subcorneal pustular with neutrophils immersed and direct immune fluorescence as well as blood and blister fluid culture were negative. Additionally, the patient showed a high expression of IL-6 (18371.09pg/mL) in peripheral blood and blister fluid (19997.89pg/mL).