Bleomycin, a selective inhibitor of DNA-dependent DNA polymerase from oncogenic RNA viruses

Abstract

Bleomycin, an antibiotic, inhibits the DNA-dependent DNA polymerase from Rauscher murine leukemia virus. Higher concentrations of BLM ∗ ∗ Abbreviations: RMLV, Rauscher murine leukemia virus; BLM, bleomycin are required to inhibit it's RNA-dependent DNA polymerase. These inhibition effects of the non-competitive type are not altered by preincubation of the DNA with BLM. Under comparable conditions neither the DNA-dependent DNA polymerase activity from E. coli and mouse liver nor the DNA-dependent RNA polymerase activity from mouse lymphoma cells are affected by BLM.