Abstract
Blends of poly vinyl alcohol (PVA) and polyglycolic acid-co-lactic acid (1:1), PGLA, were shown by DSC and electron microscopy to be miscible when the PVA content was 70wt-% or greater. The permeability coefficients of naltrexone, naltrexone hydrochloride, cytochrome C, myoglobin and somatotropin in PVA and PVA-PGLA blends ( 80:20 and 40:60 ) were measured. The permeability was proportional to the water content of the blends, which increased monotonically with the PVA content. Controlled release of myoglobin and cytochrome C from spheres coated with a PVA-PGLA (80:20) blend was achieved. The rate of hydrolytic chain scission of PGLA was relatively insensitive to the water content of immiscible blends, but increased exponentially after the blends became miscible.
Published Version
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