BLACK TILAPIA FISH (Oreochromis niloticus) SKIN EXTRACT INDUCE WOUND HEALING ON Rattus norvegicus

Abstract

Objective: The objective of this research is to evaluate the effect of black tilapia sh/BTF (Oreochromis niloticus) skin extract cream application on wound healing by assessing its effect on wound contraction, epithelial thickness, and collagenization rate. T Method: rue experiment using 36 Rattus norvegicus as research object, wounded with punch biopsy sized 8 mm on right side of the back. Research objects were divided into 6 groups (X0: no treatment; X1: cream base application on wound; X2: application of gentamicin cream; X3: application of BTF extract cream 10%; X4: application of BTF extract cream 20%; X5: application of BTF extract cream 30%. Wound contraction was evaluated on day 3, 6, 9, and 11. Tissue sample was biopsied and examined on day 11 to evaluate epithelial thickness (HE) and collagenization (mallory). Application of Result: BTF skin extract cream showed an effect on wound contraction, epithelial thickness, and collagenization rate of new wound, the higher the concentration of BTF cream given, the better the result was. BTF skin extrac Conclusion: t cream can be a new hope and alternative therapy in wound treatment.