Curcuma amada roxb. (Rhizomes) Promotes Wound Healing Process

Abstract

Object: Curcuma amada Roxb, also known as Mango ginger (Zingiberaceae), is a rhizomatous aromatic herb, used for the healing of wounds in Indian folk medicine. The present study provides a scientific evaluation for the wound healing potential of various extract of Curcuma amada Rhizome. Materials and methods: Excision wounds were inflicted upon ten groups containing six rats each. Group-1 was assigned as control (white soft paraffin), Group-2 was treated with standard silver sulphadiazine (0.1%) ointment. Group-3 and Group-4 was treated with 5 and 10% petroleum ether extract ointment. Group-5 and Group-6 were treated with 5 and 10% ethyl acetate extract ointment. Group-7 and Group-8 were treated with 5 and 10% ethanol extract ointment. Group-9 and Group-10 were treated with 5 and 10% aqueous extract ointment. The parameters observed were percentage wound contraction, epithelization period and histopathological studies. Results: Topical application of ethanolic extract ointment of Curcuma amada rhizomes (10%) in excision wound model significantly (P < 0.001) increased the percentage of wound contraction (99%) compared with control (90.%), decreased the epithelialization time and histopathological changes. Conclusion: The 10% ethanolic extract of Curcuma amada rhizomes facilitated wound healing significantly, corroborating the folk medicinal use of this plant. Keywords: Curcuma amada, Epithelialization period, Excision, % Wound contraction, Wound healing.