Abstract
The study aimed to determine the quality of bittern lotion. Furthermore, this research aimed to determine the potential of bittern lotions as anti-inflammatory tests on the skin of Swiss Strain Mice using histological analysis. The bittern sample used was obtained from a salt pond in Kedung Mutih, Demak District, Central Java Province, Indonesia. The research was conducted by making lotion bittern in the concentrations of 20 percent, 35 %, and 50 %, followed by testing lotion bittern. The data were then analysed by One-Way ANOVA, LSD test, and Independent Samples T-test. Results showed that the three bittern lotions have potential as an anti-inflammatory, with the best results being 35% bittern lotion with an inflammatory inhibition (PI) level of 29.37%. However, based on histological analysis of the number of inflammatory cells (skin tissue), there was a significant difference (P<0.05). Thus, it can be concluded that bittern lotion has the potential as an anti-inflammatory lotion.
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