Abstract
We determined aortic plasma endothelin (ET-1) concentration in juvenile pigs during six hours after acute lung injury induced by meconium aspiration. Twelve 10 week-old pigs received 3 ml/kg 20% human meconium via endotracheal tube. Six pigs were pretreated with 30 mg/kg methylprednisolone i.v. known to attenuate the acute lung injury. Another six pigs served as controls and received endotracheally 3 ml/kg sterile saline. Ventilator settings were adjusted to avoid hypoxemia.
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