Abstract
Abstract Several chemical carcinogens and non-carcinogenic analogues were tested in vitro for their capacity to affect the biosynthesis of the second (C2) and fourth (C4) components of complement. Of the compounds tested, 4-nitroquinoline-n-oxide, effective at 10-7 M, was the most potent inhibitor of C2 and C4 biosynthesis. Propriolactone and two nitroso-compounds also inhibited C2 and C4 synthesis, whereas their non-carcinogenic analogues had no effect. These findings suggest that some carcinogens interfere with at least one normal function of the immune system.
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