Abstract
Levulinic acid, a competitive inhibitor of δ-aminolevulinic acid dehydrase, inhibited chlorophyll-a and phycocyanobilin synthesis by 50% in vivo in the unicellular rhodophyte, Cyanidium caldarium. Inhibition of tetrapyrrole synthesis was accompanied by accumulation of δ-aminolevulinic acid in amounts equivalent to the difference between chlorophyll-a and phycocyanobilin synthesis in control and levulinic aicd treated cells. δ-Aminolevulinic acid produced by levulinic acid treated cells incubated with specifically labeled glycine, α-ketoglutarate and glutamate was degraded in alkaline periodate to the succinic acid (C 1-C 4) and formaldehyde (C 5) derivatives. The distribution of radioactivity in these fragments suggested that the carbon skeleton of δ-aminolevulinic acid is derived directly from α-ketoglutarate and glutamate.
Published Version
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