Abstract
Currently, silver nanoparticles (AgNPs) have been providing unique approach to the treatment of infectious diseases. Therefore, herein we demonstrate AgNPs synthesis by conventional bioreduction approach using quercetin compound from Clitoria ternatea L. methanolic petal extract. Bioreduction of silver nitrate (AgNO3) with the quercetin extract, was incubated for 240 min and the mixture were characterized by UV–Vis spectroscopy, FTIR, XRD, DLS, SEM, EDS and Zeta potential analysis. The results were confirmed the presence of silver ion. Furthermore, the biosynthesized AgNPs possess significant antimicrobial activity against multidrug resistant bacteria such as, Staphylococcus aureus and Shigella sp. with maximum concentration (100 µl) showed strong inhibitory action. In addition, the hybrid AgNPs showed potential Quorum Sensing Inhibition activity with different concentration (25–100 µg/ml) against the AHL-mediated violacein production in C. violaceum (14–86%) and biofilm formation (19–92%), extracellular polymeric substances (16–72%), protease (17–93%) productions in S. aureus and. It was again confirmed by spectrophotometry and microscopy. Further, the synthesized hybrid AgNPs showed less hemolysis activity 4.58%, compared with American Society for Testing and Materials range <5%. Threfore our findings recommend that the biosynthesized AgNPs could be more hemocompatible for drug delivery applications.
Published Version
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